Monday, September 16, 2019
Steve Jobs the Man
Steve Jobs ââ¬Å"The best leader of 05â⬠Steve Paul Jobs is the Chief Executive Officer (CEO) of Apple Inc, which he co-founded with Steve Wozniak in 1976 when he was just 21 years old. Steve Jobs is also the co-founder of Pixar Animation Studios which has grossed more than $4 billion and has won 20 Academy Awards so far. In 2006, Pixar merged with The Walt Disney Company and Steve Jobs now serves on the Walt Disney Companyââ¬â¢s board of directors and is the largest individual share holder of Walt Disney. Steve Jobs after a conflict with Appleââ¬â¢s board of directors resigned from Apple in 1985 and founded a new company called NeXT the following year. Apple Incââ¬â¢s take over of NeXT in the year 1997 reunited Steve Jobs with the company he had co-founded and became its CEO shortly after his return. Steve Jobs is known for revolutionizing the world of personal computer with his innovative user interfaces. Steve Jobs is also famous for revolutionizing the music market with his iPods and iTunes online store. Steve Jobs has also entered into the cell phone market with Apple iPhone. Apple has earned the name the most innovative consumer electronics company in the world due to the contribution of Steve Jobs. Early Life Steve Jobs was born on February 24, 1955 to Joanne Carole Schieble and Abdulfattah Jandali in San Francisco. He was adopted by Paul and Clara Jobs of Santa Clara County, California. During his school days in California he used to attend the after-school lectures at the Hewlett-Packard Company. Later he joined the company as summer employee along with Steve Wozniak. In 1972 he joined Reed College in Portland, Oregon after graduating from high school. However he dropped out of the college after one semester and spent his time in college by taking classes in philosophy and devoting time to study counterculture. In 1974 Steve Jobs went back to California and attended meetings of Hombrew Computer Club with Steve Wozniak. He joined a video games manufacturing company as a game designer. His primary motive was to save money to go on a trip to India in search of spiritual enlightenment. After saving enough money he went to India with his friend from Reed College, Dan Kottke and returned back with his head shaved and wearing traditional Indian clothes. He returned to his job at Atari and was given the task of reducing the number of chips in the circuit board for the game Breakout. Having little knowledge in design of circuit boards, Steve Jobs joined hands with Wozniak and successfully reduced the number of chips by 50. Although Wozniak was content with inventing electronic gadgets, Steve Jobs had bigger dreams of marketing the electronic products. Steve Jobs was fascinated by a computer built by Wozniak for his own use. He then persuaded Wozniak to join him in building and marketing a personal computer. Steve Jobs and Wozniak built a prototype of Apple 1 computer in Jobsââ¬â¢ garage. The prototype impressed a local electronics equipment retailer who gave an initial order of twenty five. With this initial order and a sum of $1300 raised by selling Jobsââ¬â¢ Volkswagen micro-bus and Wozniakââ¬â¢s Hewlett-Packard scientific calculator they set up their first production line. Jobs asked Wozniak to quit his job at Hewlett-Packard and take charge as Vice President of research and development of the new company. Jobs received marketing advice and strategies from a former CEO of Intel who happened to be his friend. As a result the Apple Computer Co was born on April 1, 1976. Though Apple started with the marketing of printed circuit boards it gradually entered into the personal computer business. The Birth of Apple Computer The first personal computer marketed by the Apple Computer Co. was Apple I in 1976. Apple I was sold for $666. 66. Apple I was sold as an assembled circuit board (motherboard) with CPU, RAM and textual-video chips. It lacked basic features like keyboard, monitor and a case. They had to be attached by the owner of the unit. However, Apple I was the first single-board computer with video interface and an on-board ROM. Sales of Apple I earned the company $774,000. Two years after Apple I was introduced, Jobs and Wozniak came up with Apple II which revolutionized the world of personal computers. Apple II was a huge success and dominated the home and small business personal computer industry for the next five years. Apple III was introduced in 1980 which faced stiff competition from IBM and Microsoft. Apple III had a design fault (lacked a cooling fan) which resulted in recalling of thousands of units. Apple III+ was introduced 1983 which was also a failure in the market. In 1983, Jobs felt that the company needed expert management in order to face the competition from IBM and hence lured John Sculley away from Pepsi-Cola offering him the post of CEO, calling it an opportunity for John Sculley to change the world. Apple then came up with Macintosh which was a commercially successful computer mainly because of the user friendly windows Graphical User Interface (GUI). Macintosh made the user world much easier by replacing the command lines with objects displayed on the screen which the user had to click using a mouse to perform some function. Software companies seeing the growing popularity of Macintoshââ¬â¢s interface with the public had to change their interface to accommodate picture icons or buttons to their interface. The reason behind Macintoshââ¬â¢s success was its user friendly interface, flexibility and its ability to cater to specific needs and it slowly gained the attention of big business corporations which was dominated by IBM computers. Unsuccessful NeXT Venture After the sales slump in 1984 Steve Jobsââ¬â¢ working relationship with Sculley worsened. In May 1985 Sculley and the other board of directors relieved Jobs of his managerial duties. Jobs resigned from Apple and founded a new computer company called NeXT Computer in 1986. Steve Jobs tried to recreate the magic he had done with Apple with his new company NeXT by creating a new generation of personal computers. Jobs attempts failed as the computers were highly futuristic and costly. Having failed in the hardware division Jobs tried to revolutionize the software division. Jobs felt that OOP (Object Oriented Programming) held the key to success in software development. Jobs said that OOP concept could make the programmerââ¬â¢s job much easier as the OOP approach introduced modularity which meant that programmers could complete 80% of their program using pre-written chunks of code thus saving time and money. NeXTMail and NeXTStep operating system were the other notable ventures of the new company. Return to Apple After Appleââ¬â¢s take over of NeXT for $429 million in 1996 Steve Jobs was reunited with the company he had cofounded. He replaced the interim CEO and immediately cancelled a number of ongoing projects in Apple namely Newton, Cyberdog and OpenDoc. The research in NeXT found its way in Appleââ¬â¢s products. The most important of this is the evolution of NeXTStep operating system into Mac OS X. There has been no looking back for Steve Jobs after returning to Apple. In 1997 Steve Jobs announced that Apple had entered into a partnership with Microsoft for introducing new versions of Microsoft Office tools for Macintosh. In the same year Apple opened an online retail store called Apple Store based on the WebObjects application server of NeXT. The next few years saw Apple releasing new computers like iMac, iMovie and Final Cut Pro (the latter two being special video editing systems for multimedia professionals) and new versions of Mac OS. Recently Jobs released the worldââ¬â¢s thinnest notebook MacBook air. Achievements of Steve Jobs From being a college dropout, Steve Jobs has come a long way in co-founding Apple Inc and revolutionizing the personal computer market. Through his Apple computer Steve Jobs changed peopleââ¬â¢s idea of a computer from gigantic mass of vacuum tubes restricted to big business houses and Government organizations to a user friendly small box used by the common man. Apple II was a huge success and earned the company $139,000,000 within a span of three years and the company recorded a growth of 700%. Apple dominated the industry from 1978 to 1983 and recoded a growth rate of over 150% per year. Though the NeXT venture was a commercial failure it catalyzed other important events mainly the World Wide Web. The Mac OS X is also an evolution of NeXT technology. Steve Jobs has featured on the cover of TIME magazine for five times and has appeared in the TIMEââ¬â¢s list of 100 Most Influential People in The World for four times. Steve Jobs has also been featured in the Fortune Magazineââ¬â¢s list of most powerful businessmen in the world. Under the leadership of Steve Jobs Apple Inc has earned the name ââ¬Å"the most innovative consumer electronics company in the worldâ⬠. Apple Inc has entered other computer related industries like music through iTunes store and iPod and cell phone industry through iPhone. Steve Jobsââ¬â¢ contribution to the computer industry is highly commendable. REFERENCES Burrows, P. , Grover, R. , & Green, H. (2006). Steve Job's Magic Kingdom. New York. Business Week, February 6, 2006, Issue 3970, page 62. Burrows, P. , Grover, R. , & Green, H. (2006). Steve Job's Magic Kingdom. New York. Business Week, February 6, 2006, Issue 3970, page 62. http://proquest. umi. com/pqdweb? index=15&did=979953551&SrchMod e=1&sid=15&Fmt=3&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1235502776&c lientId=29440 ââ¬Å"Steve Jobs. â⬠Wikipedia: The Free Encyclopedia. 27 Feb. 2008. ââ¬Å"Apple Inc. â⬠Wikipedia: The Free Encyclopedia. 27 Feb. 2008. Angelelli, Lee. ââ¬Å"Steve Paul Jobsâ⬠. 12 Jul. 1994. 27 Feb. 2008. ââ¬Å"The TIME 100- Are They Worthy? â⬠. TIME. com. 27 Feb. 2008. ââ¬Å"Steve Jobs CEO Apple. â⬠Apple. com. Nov. 2007. 27 Feb. 2008.
Sunday, September 15, 2019
Outsorcing
Nowadays, many companies use outsourcing to be an alternative source to do specific work, processes, and activities to get benefits from within an organization to outside providers without aware of effects on local worker or country economic. According to Reap W. (2012), some companies in United States and other area make a lot of profits from outsourcing in term of economy and businesses such as production of material product while others are suffer from transferring outsourcing job to other countries that impact on United States economic.Companies should once about local workers more than self-benefit because if they continue to destroy local Job that will cause major problem to society. According to wry. Serviette. Com, what is outsourcing (n. D. ), outsourcing is a process of hiring outside internal companies or workers from domestic or abroad to do specific work such as manufacturer, marketing or even content writing. Presently, outsourcing is very popular in slow develop countr ies such as Laos, Vietnamese, India and Thailand because several factors.According to Overly (2007), low costing, lack of n-house resource, variable capacity, access to specific IT skills, increase flexibility to meet new business and commercial conditions , these are the major factors that lead big country come to invest outsource in undeveloped country. For example, according to Matthews (2012), many U. S companies invested in India and Vietnam such as Aids, Leno. These companies mainly produce their product oversea because lower labor cost that make them produce product in cheaper price and customer can afford it.Another example is gasoline, gasoline price is continue decrease, even Hough much oil are produce from other countries so public was stated that the factor effect to gas prices are more money spend needs and other wants. According to Plunked research, ââ¬Å"Introduction of outsourcing and offshore industry', one of outsource service very popular and continue to be stron g hiring thousands of Jobs to work in China and India is engineer and researcher that in 2010, the number of worker in IBM is from oversea is over 80000 people and it reached to 112000 people in 2012.These examples were connected to the reasons of manufactured goods and sots, materials and services. Outsourcing causes local worker who live or work in developed country lose their Job. According to Mapping (2008), outsourcing purpose is to cut production cost by hire other foreign companies and workers to do specific work so it leads to people losing Job and 40 percent of US company is sending Job to foreign countries and over 31 percent of US citizen are lose their Job. This statistic seems obvious that outsourcing make US citizen loses their Job and it can connect to major problem.For example, according to kimono (2009), an increase of trade U. S. Jobs to oversea as well as increase of Jobs losses that has impact on U. S. Economy as a whole such as MM, Ford Motor and GE Capital have sent a high number of Jobs to other countries and chosen employ cheap labor instead of hiring worker in their country. According to the article ââ¬Å"what is outsourcingâ⬠, one of the major factors companies choose outsourcing is cost of outsourcing that can reduce amount of money by outsourcing some of the Jobs and tasks such as content creation and server monitoring and management.According to Alex (201 1), a research shows the estimate number of outsource in 201 5 is 3. Millions Job send to oversea as a result thousand of U. S Jobs will be lost each year and it leads to be shutdown country economic and that layoff can cause stress on human mind and lives. For example, some common depression symptoms are feelings of worthlessness, helplessness, guilt, fatigue, insomnia and restlessness, according to Empower. Some symptoms of anxiety include worrying, obsessive thoughts, fear, panic, impatience, concentration problems, rapid or irregular heartbeat and nausea.Moreover, outsou rcing can make many Jobs at risk to distinct, according to Opposing viewpoint ââ¬Å"Legislation to Limit Outsourcing Is Essential and Effectiveâ⬠, The Bureau of Labor Statistics shows that about 51 5 occupations are at risk to distinct and 160 of these Job are change to be offshore outsource and over 300,000 occupations will disappear annual after year 2015. These reasons have showed that outsourcing causes Job losing, slow development and mental illness on people. Moreover, outsourcing causes global economic crisis which is major problem to every country because it can affect to world economic.According to Rather (2014), who has a PhD in organic chemistry from Oxford University as well as a Bachelor of Technology n chemical, In 2013, the number of unemployment is increased millions people that causes global economic crisis, in contrasted, India, a country which education has just boomed, there are now has fewer people unemployment than U. S. ââ¬Ës. According to Losing Jobs , The real impact of the Economic Crisis (2012), ââ¬Å"As more and more businesses go to the wall, rising unemployment levels are a clear and devastating indication of the problems that workers are facing worldwide.The International Labor Organization is forecasting that more than 50 million workers could lose their bobs this year and up to 200 million more will be plunged into extreme poverty. The Organization for Economic Cooperation and Development says that by next year jobless numbers in rich nations could rise by eight million to 42 million. The UK has just registered the biggest quarterly Jump in unemployment since the 1981 depths of recession. â⬠This is a result from outsourcing that lead to local worker in U.S loses their Job and it may lead to major problems. For example, according to Junker (n. D. ), investment in real capital cities is stagnant and a lot of consumers have slowed Roth in paying money and it make economic crisis. These factors are connected to slowe r develop country and if this continue to long-term protesting will happen in finally. On the other hand, outsourcing can improve country economy and develop country standard. According to Grant G. (n. D. ), outsourcing can offer over 90000 Jobs to local worker and foreign worker in 2003 that U.S. Companies use offshore sourcing lower costs, to allow them to hired U. S. By called for a tax credit to help pay extra money for American companies which agreed to stop hiring worker overseas operations to take umber of Jobs back to American land as part of his ââ¬Å"incurringâ⬠agenda. Surprisingly, more than 100,000 IT Job software and hardware are moved to other countries , but the number of U. S. Job is created more than 90000 as the result from cost saving and offshore outsource. However, outsourcing can destroy country economy and overview of country.For example, outsourcing causes major problem by job losing when people lose Job, they will concern their money how to live, how to spend their money as the result they will spend money less and country economic will struggle then country will slower developed. Moreover, when people get more stress and it over limited that person can cope with, they will suicide and this problem will bring overview of country get worse so these can demonstrate that outsourcing can cause many problem that a problem connected to other and it will be major issue.In sum, U. S. Companies and government should cooperate to reduce number of using outsource to solve the following problems that will happen after offshore order to relief economic crisis and decrease number of unemployment that caused by outsourcing.
Saturday, September 14, 2019
Malcolm X a Homemade Education
Elizabeth Terry Biology 101-06 MWF at 3:00 November 14, 2011 Research paper DOWN SYNDROME Down syndrome is the most common cause of mental retardationDown syndrome is the most common cause of mental retardation. It is caused by the presence of an extra chromosome. Chromosomes contain sequences of DNA called genes that represent the genetic information that exists within a cell. Twenty-three distinctive pairs of chromosomes which is 46 in total. They are located within the nucleus (a region of the cell that is bounded by a specialized membrane, and which houses the genetic material).When a sperm cell fertilizes an egg cell, the newly created zygote normally receives 23 chromosomes from each parent. The contribution of genetic information from each parent is what makes each baby a distinctive blend of both characteristics. In Down syndrome a mistake during division of the sperm or egg cell produces a cell with an extra chromosome 21. This event occurs during cell division and is referr ed to as nondisjunction, or the failure of all chromosomes to separately properly resulting in retention of one of the chromosomes in one of the two new daughter cells.This is also called trisomy 21 and is accounted for 95% of all Down syndrome patients. A rare number of Down syndrome cases the original egg and sperm cells begins with the correct number of chromosomes but shortly after fertilization during the phase where cells are dividing rapidly a single cell can divide abnormally creating a line of cells with an extra chromosome 21. Itââ¬â¢s called a cell line mosaicism. The individual with this type of down syndrome has two types of cells: some 46 chromosomes which is the normal number and some with 47.Individuals who are mosaic for trisomy 21 typically have less sever sign and symptoms of the disorder. Another are location that can cause down syndrome is called a chromosome translocation. This is an even that unlike the numerical abnormally causing trisomy 21, there is a st ructural abnormality. Exchange of material from two different chromosomes during the production of sex cells can take place such that there is a whole chromosome 21 attached to another chromosome but the chromosome number is normal. [1]These types of translocation involving chromosome 21, occur in about 3-4% of cases of Down syndrome.Ancient cultures, such as those in Greece, Rome, and Egypt, put disabled infants to death. Compassion toward the disabled was awakened by the early Christian church, but its charitable influence waned during the middle ages. Down syndrome also affected this people due to no one really caring about what was going on with the ill children. Down syndrome has a lot of causes and this is normally what some parents want to know is why their child is born with this syndrome. Most times this is why they tell you while you are carrying your child you need to watch very closely and look for all signs of genetic disorders with pregnant.Down syndrome is a chromosom al disorder as I said before. A baby is usually identified at birth through observation of a set of common physical characteristics. Babies with Down syndrome tend to be overly quiet. When I say that I mean less responsive with weak floppy muscles. With that being said a number of physical signs might be present. This includes a flat bridge of the nose which is smaller than normal. Itââ¬â¢s a low set nose. They will tend to have a small mouth with a protruding tongue, upward slanting eyes and also extra folds of skin located at the corner of each eye, near the nose.They will have small outwardly rotated ears and small hands as well. Usually they have an unusual deep crease across the center of the palm and a malformed fifth finger. They will have a wide space between the big and the second toes and unusual creases on the soles of the feet. They also experience shorter than normal height later on in their childhood. Before genetic testing became available, Down syndrome was diagno sed based on certain typical physical characteristics. Not all people with Down syndrome have all these characteristics though.This can vary from certain people and are caused by the extra chromosomes. Individuals with Down syndrome also have joints that are looser than normal. Their skulls are short and broad. Newborns usually have extra skin on the back of their neck, and as the child gets older the neck often appears short and wider than usual. [2]Facial shape is round in the newborn and also during infancy. When the child gets older their face shape becomes oval like. This is due to the underdevelopment they go through. Their cheeks are round and the teeth develop late and in an unusual order.Although Down syndrome is not curable and there will be no cure for it, parents, researchers, and also the Down syndrome individuals try to make the best out of life and try dealing with it. Advances in medical treatment over the past 40 to 50 years for conditions such as heart defects and respiratory disease have led to dramatic increases in the life expectancy of those with Down syndrome. [3] Half of the children born with Down syndrome during the late 1960s survived to age 5. Bronchopneumonia, a respiratory illness and heart defects were the most common causes of death.Now about 80% of those born with it survive to age 10, and about 50% of them survive to age 50 or beyond. The recent statistics from various study places show that the place of incidence of Down syndrome anywhere from 1 in 600 to 1 in 1,000 live births. An analysis published by various people. Bray and colleagues in 1998 of combined data from nine different studies found that the incidence varies from 1 in 1,445 live birth mothers at age 10 to 1 in 25 live births to mothers at age 45. Down syndrome really is a hard disorder to live with but at the same time it has its advantages.Down syndrome has no treatment options but they have a lot of programs to help cope with this syndrome. The development of a child is a joyous thing. It involves amazing ohhs and ahhhs that would shock you every day your child does something new. All kids from the time their able to sit up by them and walks are learning new things everyday. Even as adults we learn new things everyday but still with Down syndrome, everything that they accomplish is outstanding. All kids learn to develop their fine motor skills but there are different aspects when it comes to Down syndrome children.The development of motor skills is very hard. The first thing you have to do is have a laid out foundation of how you plan on teaching that child. This is very dependent on stability. [4]Stability is being able to push open a heavy door. Itââ¬â¢s being able to put on your shoes without falling. It is carrying a tray full of drinks. Its really a list that goes on but with this syndrome most things arenââ¬â¢t accomplished because down syndrome babies lack stability. Most of the people diagnosed wit this syndrome also tends to walk a little strange. They walk from side to side and always have their head twisted.Now as kids get older and reach their age past ten, then your not exactly ok, but you can breathe a little. Most researchers are still concerned about the older ones but its really the babies that most are worried about. They tend to go through a lot as newborns and unto there early infants stages. [5] Babies with Down syndrome suffer a lot. They have a lot they feel and go through, but being an infant and not being able to talk doesnââ¬â¢t help at all. Being born with Down syndrome you experience how it is from that point on and for the rest of your life.Children with this syndrome almost always have some degree of intellectual disability. That is why they learn slower and have difficulty with complex reasoning and judgment. The degree of intellectual impairment various tremendously. These kids do learn and what they do learn they will not forget. Down syndrome can not be prevented but it is People with Down syndrome, whatever their age, are people first. They are people with abilities, strengths and weaknesses like everyone else. They may have additional needs but first they have the same needs as everyone else of their age group.The quality of health care, education and community support provided to children and adults with Down syndrome makes a real difference to their progress throughout life. This module provides an introduction to all the issues that need to be addressed to enable individuals with Down syndrome, and their families, to enjoy full and happy lives within their communities. It offers an overview of the development of individuals with Down syndrome from infancy to adult life. It also provides a summary of the causes of Down syndrome, the incidence and prevalence of the condition, life expectancy and associated education and health care needs.Children with down syndrome experience problems with their digestive tract at a rate that is much higher than t hat of other children. [6] some of these problems such as blockage of the digestice tract can be life threatening and can require emergency surgery. Blockage or atresia of the esophagus or the duodenum can cause starvation if not corrected. Atresia occurs when the anal opening does not develop. This condition prevents solid waste from being eliminated from the intestinal tract and must be corrected surgically. Anal stenosis will allow waste products to pass, but will cause constipation.Gastroesophageal feflux is also more common in individuals with down syndrome. During this stage food reenters the esophagus from the stomach. This can cause vomiting and irritation of the esophagus. You can also have vision problem s with down syndrome to. Theses problems are common with those suffering with down syndrome. Strabismus in which one or both euyes either truns in or out. Occurs in 43% of theses chuldren. It is caused by abnormal or incomplete development of the cneters in the brain that control the coordination of eye movements. This condition may require an eye patch, special glasses or even surgery.Vision therapy may also be benificial and should be considered before surgery. Hearing problems also come with syndrome. [7] anatomical differences that result from trisomy 21 contribute to the larger percentage of hearing difficulties founf in individuals with down syndrome. Appromately 53% in children with down syndrome have hearing problems. This makes it more difficult to examine the ars for wax buildup and infection. The middle ear is smaller than normal, as well. This contributes to the presence of chronic ear infections in 40% to 60% of children with downs syndrome.The shallow nasal bridge founfd in 61% of individuals with down syndrome also contributed. Collapse or blockage of the eustachian tube, which leads from the ear to the throat, causes fluid to build up in the middle ear and increases the risk of middle ear infection. [8]In children with down syndrome t he eustachian tubes are often smaller tha normal and have lowered muscle tone. Problems with fluid build up in the middle ear occur in 60% of indiviuals with down syndrome this fluid buildup interferes with hearing and can cause permanent hearing loss if it remains for a long peopif of time.Estimates of hearing loss in people with down syndrome range from 60% to 80%. Hearing loss in children can contribute to language and speech difficulies as well as auditory attention. Monitoring for fluid buildup and infections of the middle ear should begin before the age of six months and should continue into adulthood. Hearin aids may be a choice as well. Another problem that occurs in down syndrome individuals is problems with thyroid gland. Weighing less than one ounce the thyroid is actually one of the largest endocrine glands. Thyroid hormones help regualte the synthesis of growth factore and many hormones.Thyroid hormones are crucial for proper brain development during pregnancy. They are also important in normal growth. Because they are composed of the amino acid tyrosine, to which iodine molecules have been atattched adequate iodine in the diet is esstenial for their production. Another hormone produced by the thyroid gland is calcitonin which regulates the levels and metabolism of calcium. The hormones tri-iodothyonine and tetraiodothyonine are produced by the thyroid gland in a ratio of 1;14. t4 is secreted by the thyroid gland in responses to TSH. The active form, T3 is formed in the kidney, liver, and pleen by removal of one iodine molecule from T4. individuals with down syndrome also are 10 to 30 times more likely to develop Leukemia. [9] This is a type of cancer caused by the production of abnormal qhite blood cells by the bone marrow. These abnormal cells eventually crowd out normal white and red blood cells. There are two main types of leukemia. Acute and chronic. Acute leukemias develop slowly and the patienst condition worsens slowly. Chronic leukemia de velops rapidly and the patients syptoms worsen quickly. About 10% of babies born with down syndrome develop a transient leukemia that usually goes away by 3 months of age.About 20% to 30% of those with this transient condtion go on to develop acute leukemia. Babies who do not have down syndrome rarely have the transient form of leukemia. This higher risk of leukemia is in contrast to the risk of other types of cancer in individuals with down syndrome. The incidence of most types of solid tumors is muh smaller than in the general population. Down syndromes rates has also increased. From 1979 to 2003, the prevalence (total number of cases of a disease in a population at a specific time) of Down syndrome (DS) at birth increased by 31 percent, from 9 to 12 per 10,000 live births in 10 US regions.Within the 10 regions, birth prevalence of DS ranged from a low of 9. 7 in Arkansas to a high of 13. 7 in Utah during 1997-2003. The number of infants born with DS was almost 5 times higher amon g births to older mothers (38. 6 per 10,000) than among births to younger mothers (7. 8 per 10,000). In 2002, DS was found to be present in about 1 of every 1,000 children and adolescents aged 0 to 19 living in 10 chosen regions of the United States, which means that approximately 83,000 children and adolescents with DS were living in the United States during that year. Prevalence of DS by age group was the highest in 0-3 year olds at 11. , declining to 10. 3 among 4-7 year olds, 9. 8 among 8-11 year olds, 8. 3 among 12-15 year olds, and 6. 0 among 16-19 year olds. A screening test will help identify the possibility of Down syndrome. Screening tests do not provide conclusive answers, but rather, they provide an indication of the likelihood of the baby having Down syndrome. An abnormal test result does not mean that your baby has Down syndrome. The goal with a screening test is to estimate the risk of t baby having Down syndrome. If the screening test is positive and a risk for Down syndrome exists, further testing may be recommended.Diagnostic tests can identify Down syndrome before the baby is born. January issue of Obstetrics & Gynecology, the American College of Obstetricians and Gynecologists released guidelines recommending screening for Down syndrome to all pregnant women during their first trimester. Agnostic tests tend to be more expensive and have a degree of risk; screening tests are quick and easy to do. However, screening tests have a greater chance of being wrong; there are ââ¬Å"false-positiveâ⬠(test indicates the baby has the condition when the baby really does not) and ââ¬Å"false-negativesâ⬠(baby has the condition but the test indicates they do not).As far as those individual kids with Down syndrome there is a lot that they can do, just as the regular ones. Kids with Down syndrome tend to have a sense of humor. Those with this disorder have slurred words and stutter but what you can understand they have pretty good conversation. Also in about 4 percent of all down syndrome cases the individual possesses not an entire third copy of chromosome 21 material, which has been incorporated via a translocation into a no homologous chromosome. In translocation pieces are swapped between two non-related chromosomes forming hybrid chromosomes.The most common translocation associated with Down syndrome is that between the long arm (down gene area) of chromosome 21 and an end of chromosome 14. [10] The individual in whom the translocation has occurred shows no evidence of the aberration since the normal complement of genetic material is still present only a different chromosomes location. The difficulty arises when this individual forms gametes. A mother who possesses the 21/14 translocation, for example has one normal 21 one normal 14 and the hybrid chromosomes.She is a genetic carrier for the disorder because she can pass it on to her offspring even though she is clinically normal. The mother can produce three types of viable gametes: one containing the normal 14 and 21. the presence of an extra copy of the long arm of chromosome 21 causes defects in many tissues and organs. One major effect of Down syndrome is mental retardation. The intelligence quotients of affected individuals are typically in the range of 40-50. The IQ varies with age but being higher in childhood than in adolescence or adult life.The disorder is often accompanied by physical traits. Trisomy 21 is one of the most common chromosomal aberrations occurring in about 0. 5 percent of all conceptions and in one out of every seven hundred to eight hundred live births. About 15 percent of the patients institutionalized for mental deficiency suffer from Down syndrome. Before the chromosomal basis for the disorder was determined the frequency of Down syndrome births was correlated with increased maternal age. For mothers at age twenty the incidence of down syndrome is about 0. 5 percent which increases to 0. 9 percent by the age thirty -five and 3 percent at age forty-five. Comparing the chromosomes of the affected offspring with those of both parents have shown that the nondisjunction event is maternal about 75 percent the time. The maternal age effect is thought to result from the different manner in which the male and female gametes are produced. Gamete production in the male event in females. Formation of the femaleââ¬â¢s gametes begins early in embryonic life, somewhere but between the eight and twentieth weeks.During this time, cells in the developing ovary divide rapidly by mitosis forming cells called primary oocytes. These cells then begin meiosis by pairing up the homologues. The process is interrupted now and the cells are held in a state of suspended animation until needed in reproduction, when they are triggered to complete their division. Most individuals with Down syndrome have intellectual disability in the mild (IQ 50ââ¬â70) to moderate (IQ 35ââ¬â50) range, with individuals having Mosai c Down syndrome typically 10ââ¬â30 points higher. Dr.Weihs notes the mental qualities of people with Down syndrome to be ââ¬Å"unisexual,â⬠ââ¬Å"playful,â⬠ââ¬Å"affectionate,â⬠ââ¬Å"mischievousâ⬠and ââ¬Å"imitativeâ⬠. [21]Language skills show a difference between understanding speech and expressing speech, and commonly individuals with Down syndrome have a speech delay. Fine motor skills are delayed and often lag behind gross motor skills and can interfere with cognitive development. Effects of the condition on the development of gross motor skills are quite variable. Some children will begin walking at around 2 years of age, while others will not walk until age 4.Physical therapy, and/or participation in a program of adapted physical education (APE), may promote enhanced development of gross motor skills in Down syndrome children. A 2002 literature review of elective abortion rates found that 91ââ¬â93% of pregnancies in the United Kingdom a nd Europe with a diagnosis of Down syndrome were terminated. [54] Data from the National Down Syndrome Cytogenetic Register in the United Kingdom indicates that from 1989 to 2006 the proportion of women choosing to terminate a pregnancy following prenatal diagnosis of Down syndrome has remained constant at around 92%.In the United States a number of studies have examined the abortion rate of fetuses with Down syndrome. Three studies estimated the termination rates at 95%, 98%, and 87% respectively. Medical ethicist Ronald Green argues that parents have an obligation to avoid ââ¬Ëgenetic harm' to their offspring, and Claire Rayner, then a patron of the Down's Syndrome Association, defended testing and abortion saying ââ¬Å"The hard facts are that it is costly in terms of human effort, compassion, energy, and finite resources such as money, to care for individuals with handicapsâ⬠¦People who are not yet parents should ask themselves if they have the right to inflict such burde ns on others, however willing they are themselves to take their share of the burden in the beginning some physicians and ethicists are concerned about the ethical ramifications of the high abortion rate for this condition. [59] Conservative commentator George Will called it ââ¬Å"eugenics by abortionâ⬠. 60] British peer Lord Rix stated that ââ¬Å"alas, the birth of a child with Down's syndrome is still considered by many to be an utter tragedyâ⬠and that the ââ¬Å"ghost of the biologist Sir Francis Galton, who founded the eugenics movement in 1885, still stalks the corridors of many a hospitalâ⬠. Doctor David Mortimer has argued in Ethics & Medicine that ââ¬Å"Down's syndrome infants have long been disparaged by some doctors and government bean counters. Some members of the disability rights movement ââ¬Å"believe that public support for prenatal diagnosis and abortion based on disability contravenes the movement's basic philosophy and goals.Peter Singer argued t hat ââ¬Å"neither hemophilia nor Down's syndrome is so crippling as to make life not worth living from the inner perspective of the person with the condition. To abort a fetus with one of these disabilities, intending to have another child who will not be disabled, is to treat fetuses as interchangeable or replaceable. If the mother has previously decided to have a certain number of children, say two, then what she is doing, in effect, is rejecting one potential child in favor of another.She could, in defence of her actions, say: the loss of life of the aborted fetus is outweighed by the gain of a better life for the normal child who will be conceived only if the disabled one dies. Individuals with Down syndrome have a higher risk for many conditions. The medical consequences of the extra genetic material in Down syndrome are highly variable and may affect the function of any organ system or bodily process. Some problems are present at birth, such as certain heart malformations. Ot hers become apparent over time, such as pilepsy. Other things Down syndrome patients go through are very emotional. For people with Down syndrome it is very hard to cope with the everyday activities. It is also hard on the family, especially the parents. It can be very frustrating for the parents to cope with having a child with Down. People born with Down syndrome require so much more extra attention than that of a normal child. Suggestions from some psychologists are for the parents to go to some kind of group sessions to talk to other parents who have children with Down.Therefore, someone else can understand the frustrations that they go through in raising their child. People with Down syndrome have a lot of different emotions running through their mind and body. People with Down syndrome, whatever their age, are people first. They are people with abilities, strengths and weaknesses like everyone else. They may have additional needs but first they have the same needs as everyone else of their age group. The quality of health care, education and community support provided to children and adults with Down syndrome makes a real difference to their progress throughout life.This module provides an introduction to all the issues that need to be addressed to enable individuals with Down syndrome, and their families, to enjoy full and happy lives within their communities. It offers an overview of the development of individuals with Down syndrome from infancy to adult life. It also provides a summary of the causes of Down syndrome, the incidence and prevalence of the condition, life expectancy and associated education and health care needs. Further modules in this series address each of these issues in detail.Down syndrome patients also have another way to look at things. The most of the time feel different and out of place. Most would like to know who Down syndrome affects. For instance what race and what are the ratios of living past a teenager Children and adults with Down syndrome have a wide range of abilities. A person with Down syndrome may be very healthy or may have unusual and demanding medical and social problems at virtually every stage of life. Itââ¬â¢s important to remember that every person with Down syndrome is a unique individual. Each child will develop at his or her own pace.It may take children with Down syndrome longer than other children to reach develop Down syndrome cannot be cured. However, early treatment can help many people with Down syndrome to live productive lives well into adulthood. Children with Down syndrome can often benefit from speech therapy, occupational therapy, and exercises to help improve their motor skills. They might also be helped by special education and attention at school. Some of the medical problems common in people with Down syndrome, like cataracts, hearing problems, thyroid problems, and seizure disorders, can be also treated or corrected.It has been suggested that children with Down sy ndrome might benefit from medical treatment that includes amino acid supplements and a drug known as Piracetam. Piracetam is a drug that some people believe may improve the ability of the brain to learn and understand. However, there have been no controlled clinical studies with Piracetam to date in the U. S. or elsewhere that show its safety and efficacy. The life expectancy for people with Down syndrome has increased substantially. In 1929, the average life span of a person with Down syndrome was nine years. Today, it is common for a person with Down syndrome to live to age 50 and beyond.In addition to living longer, people with Down syndrome are now living fuller, richer lives than ever before as family members and contributors to their community. Many people with Down syndrome form meaningful relationships and eventually marry. Now that people with Down syndrome are living longer, the needs of adults with Down syndrome are receiving greater attention. With assistance from family and caretakers, many adults with Down syndrome have developed the skills required to hold jobs and to live semi-independently mental milestones, but many of these milestones will eventually be met.Therefore, parents should not compare the progress of a child with Down syndrome to the progress of other siblings or even to other children. [pic][pic] [pic] ââ¬âââ¬âââ¬âââ¬âââ¬âââ¬âââ¬âââ¬â [1] Down syndrome K. Le Lerner Pg. 1377. Paragraph 1. [2] Genes and Disorders. By Fay Evans-martin. Pg. 14 paragraph 2. [3] Fay Evans-martin Pg. 17 Paragraph 3. [4] [5] [6] Genes & Disease By: Fay Evans Pg. 67 [7] Genes and Disorders Br Fay Evans Pg. 71 [8] Genes And Diseases By Fay Evans Pg. 71 [9] Pg. 75 Genes And Disorders By Fay Evans [10] Down syndrome medical guide. Pg. 749
Friday, September 13, 2019
Black Fly Beverage Company Essay Example for Free
Black Fly Beverage Company Essay Black Fly Beverage Company is a small beverage company based in London Ontario. The company has achieved recent success in the selling and promoting of their first alcoholic beverage, the cranberry/blueberry vodka cooler. The immediate success of this product presents two critical issues that the company must address. These critical issues are: â⬠¢Black fly must expand its product mix in order to capture a larger market share in order to compete with larger established brands within the market place â⬠¢Black Fly must also address capacity issues that will arise with an increase in demand or introduction of a new flavor Analysis. Current Situation Black Flyââ¬â¢s cranberry-blueberry vodka cooler has been well received by consumers due to its natural tasting ingredients and no chemical sweeteners producing a premium product different than existing similar beverages. The company now must take this opportunity to give their consumers another product to further explore the brand. Attempting to penetrate deeper within their current product will not allow its customers to further explore their favorite brand of vodka cooler. This will cause Black Fly to begin to lose their customers to other competing companies that offer multiple products and flavors (see exhibit 9). Black Fly also must also address the companyââ¬â¢s capacity issues in order to allow them to meet the LCBOââ¬â¢s average order lead-time of seven days. At full capacity Black Fly is meeting the required lead time with minimal margin of error to account for delays, however, during the holiday season, which will occur as early as next month, the company will not be able to keep up with the increase in demand and will fail fulfill the LCBOââ¬â¢s order in time (see exhibit 7). Options The first option available to Black Fly would be to expand its product mix with the addition of a new flavor to compliment their existing cooler. The company will be able to take advantage of economies of scale through the current production; therefore a minimal cost of $30,000 will only be needed to cover development and merchandising fees. To cover this initial cost Black Fly will have to sell an additional 127 cases a month to break even, an increase of 10. 58% (see exhibit 2). It has been projected that adding another flavor to the product line could increase sales by 50 to 75 percent. This projected increase in sales would produce an annual expected ROI of 373% and 609% respectively (see exhibit 5). If however sales increased by only 10% due to the risk of cannibalization of their original recipe then the expected ROI would be -5% (see exhibit 5). This increase in sales however will put additional strain on the companyââ¬â¢s current capacity (see exhibit 8). A second option to Black Fly would be the addition of a new specialty spirit-based product called ââ¬Å"Spiked Iceâ⬠. This packaged ready to freeze cooler would be a non-competing product to the already successful cranberry-blueberry vodka. An advantage to this product is that there is no other product similar to it out in the marketplace. The LCBO has also committed to sell 8,000 cases of the product over the four summer months, which would produce revenues of $277,200 (see exhibit 3). Over this four month period this option will produce an ROI of 15% (see exhibit 6). To produce ââ¬Å"Spiked Iceâ⬠the company however will have to purchase expensive machinery costing $500,000 and spend an additional $40,000 on merchandising and product development. To cover these costs Black Fly would have to sell an additional 7,585 cases of ââ¬Å"Spiked Iceâ⬠(see exhibit 4). This may prove difficult as this new product is very seasonal producing higher sales in the summer months and potentially smaller sales in the fall and winter months, a time in which the LCBO has not committed to sell this product at this time. Another disadvantage to this option is the space that this new machinery would occupy in the already small warehouse. Black Flyââ¬â¢s current facilities cannot produce ââ¬Å"Spiked Iceâ⬠and the original vodka simultaneously which would result in Black Fly loosing monthly revenues of $23,641 (see exhibit 1). Recommendation It is apparent that Black Fly must attempt to offer a variety of products to enhance its product mix and to keep current customers from trying other flavors offered by other competitors. At this time the best way to proceed with this will be to launch a new flavored vodka to compliment the already successful cranberry-blueberry vodka. The low initial costs and economies of scale gained through this option will allow Black Fly to introduce this new flavor quickly and efficiently to capitalize sales during the upcoming holiday season. To help address the concern of future capacity issues it would be recommended that Black Fly hire two more part-time workers and to run the production process seven days a week. This will be possible due to the expected high ROI associated with this option. This increase in production will allow the company to complete six full runs amounting to 3000 cases within the seven day lead time required by the LCBO ( see exhibit 10). In the future it will become necessary to upgrade to a larger facility and at that time it would be beneficial to begin producing ââ¬Å"Spiked Iceâ⬠, however at this current time, given the companyââ¬â¢s limited time in the market, it is suggested that Black Fly only pursue the launching of a new flavor. After the company has received sales from the holiday season the company will then be able to better address the possibility of relocating to a new warehouse and address their plans for ââ¬Å"Spiked Iceâ⬠for the upcoming summer months. Black Fly Beverage Company. (2017, Feb 27).
"Development is only concerned with the economic growth of a Essay
"Development is only concerned with the economic growth of a country" discuss - Essay Example Another aspect of development concerns the policies and programs to deliver services to members of a society. It may also be measured through business strategies for a given economy such as offering finance and expansion of the markets for produced goods. The primary objective of economic development is to ensure the improvement of society membersââ¬â¢ well-being through strategies that involve job creation, improvement of quality of life, and improve government revenue. In most developed economies, several of the aforementioned factors exist in major sectors (International Economic Development Council 3). Economic development and growth vary. Usually, they are measured based on the effects that they create on the population (La 1). For most instances, economic growth measures a generalized increase in the levels of national income and Gross Domestic Product. The method of measurement does not cater for the quality of life of the population. Such a statement means economic growth does not measure the quality of life of the society members. It is possible to realize economic growth without economic development. The rationale for such an argument is that the latter aspect of the economy weighs human capacity development. The main human factors for this case sum to both the quality of life and the standards of living. An economy can grow without catering for aspects such as reduced illiteracy, poverty elimination, creation of sufficient goods and services among others. It would therefore, imply that the economy exploits the citizens by unfair means such as long hours of working with low payments. Sustainable development gives economic development a task of improving the qualities of lives of citizens. The approach of sustainable economic development targets an increased production of goods and services to the growing population. There was, therefore, a need that the economists devise a method that would see the dreams of economic plans. Consequently, after the
Thursday, September 12, 2019
What are the strengths and weaknesses of a federal system of Research Paper
What are the strengths and weaknesses of a federal system of government Is it better than a unitary system of government Why or why not Be specific - Research Paper Example There is another advantage that states are able to settle its own policies and regulation to govern themselves, this system ensures government to remain close with people so they can be acquainted with necessitate and wants of the people. The weakness of this system is that there is a different system and each state government that can lead to over-lapping contradictory policies in various parts of the country. This system creates inequality between the states and this may steer the states to unhealthy hostility among them. Misuse of power can lead governments to corruption and in federal system corruption is very frequently practiced. (Baluyot) In unitary system, political and governing power resides with central government. In this system the central government usually delegates command to sub-national units and guide policy verdicts for implementation. This system is in contrast of federal system (K). Federal government system is better than a unitary government system because it has multiple hierarchy levels with central and local authority, also the central policy dominates over state policy and it is shared between national and local levels. But in unitary government there is no hierarchy of independent powers, states have no authority to pass their own laws, central government is the sole power to issue directives to do
Wednesday, September 11, 2019
How telecommunication has shaped the work place Research Paper
How telecommunication has shaped the work place - Research Paper Example 1). Another more detailed definition of the term disclosed its meaning as the ââ¬Å"science and technology associated, in general, with communications at a distance. A telecommunications system requires a analog or digital transmitter, a compatible receiver, and a physical (cable or wire) or non-physical (wireless) connectionâ⬠(Web Finance, Inc., 2013, par. 1). Messerschmitt (1996) revealed that ââ¬Å"the term telecommunications is derived from ââ¬Å"teleâ⬠, meaning at a distance, and ââ¬Å"communicationsâ⬠, meaning exchanging of informationâ⬠(p. 1). If defining the term apparently generated voluminous results, one was more intrigued on how telecommunications have evolved and impacted the contemporary work setting. In this regard, the current discourse aims to present the impact of telecommunications in contemporary work settings, or how telecommunications have significantly shaped the work place. Historical Overview of Telecommunications A discussion on the historical background of telecommunication actually traced its origins from the discovery of the telephone by Alexander Graham Bell in 1876 (von Alven, 1998), 137 years from now. Previous to that, it was interesting to note that forms of communication included fire signals, carrier pigeons, and even a line of canon that relayed relevant messages (von Alven, 1998). Also, other communication patterns such as the Chappe brothersââ¬â¢ semaphore system which ââ¬Å"consisted of movable arms on a pole whose positions denoted letters of the alphabetâ⬠(von Alven: Early Beginnings, 1998, par. 1) and the electric telegraph were also noted. Telecommunications in the 21st century has evolved in a rapidly changing pace due to the merging with the computer industry and the emergence of the Internet (Messerschmitt, 1996). As such, it pervaded vast industries and endeavors that transformed diverse facets of the work setting through increased access to information and through the use of ne w technologies and communications facilities that provided new applications in faster, greater and wider scope. The statistics from axvoice.com (2013) presented the changes in market shares of telecommunications in the United States from 2010 to 2015, as shown in Figure 1 below: Figure 1: Changes in Market Shares of US Telecom, 2010 to 2014 Source: Axvoice, 2013 Effect of Telecommunications in the Work Setting Telecommunications have evidently transformed contemporary work settings in terms of eliminating barriers to time, space, and locations. As confirmed ââ¬Å"advances in telecommunications have not only untethered people from desks, but they have also made it possible for people who might traditionally be unable to be in the workforce- such as those who are caring for children, or those who are disabled- to have exciting jobs and contribute to the business communityâ⬠(Alexis, 2010, par. 7). The evolution of telecommunications have enabled the establishment of diverse work settings, from the traditional office-based work place to varied work centers (Kurland & Bailey, 1999). Due to developments in telecommunications, there emerged four distinct work settings such as home-based; use of satellite offices; the existence of neighborhood work centers; and mobile working (Kurland & Bailey, 1999). This provided greater opportunities for increasing productivity, higher morale, lesser absenteeism, and minimizing costs and expenses. Likewise, through developments accorded by increased access
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